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Aftin-4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aftin-4图片
CAS NO:866893-90-5
规格:98%
分子量:368.48
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Aftin-4是β-淀粉样蛋白42(Aβ42)的诱导剂。
CAS:866893-90-5
分子式:C20H28N6O
分子量:368.48
纯度:98%
存储:Store at -20°C

Background:

Aftin-4 is an Amyloid-β42 (Aβ42) inducer.


Aftin-4 selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM[1].


Aftin-4 increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40 or Aβ1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42 content, up to +216% at the highest dose tested[1].


[1]. Meunier J, et al. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative. J Alzheimers Dis. 2015;44(2):507-24.