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Vibunazole(BAY-N-7133)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vibunazole(BAY-N-7133)图片
CAS NO:80456-55-9
规格:98%
分子量:309.79
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Vibunazole是一种新型的抗真菌唑。
CAS:80456-55-9
分子式:C15H20ClN3O2
分子量:309.79
纯度:98%
存储:Store at -20°C

Background:

Vibunazole is a new antifungal azole.


Vibunazole is an antifungal azole. Low concentrations of all three drugs inhibit Coccidioides immitis, strain Silveira, in vitro with a descending order of activity ketoconazole>Vibunazole>BAY 1 9139[1].


The untreated, infected mice lost weight initially and progressively, whereas treated mice gain weight after an initial loss with Vibunazole (all doses), BAY 1 9139 and ketoconazole at 2.5 mg/kg/day. With both Vibunazole and BAY 1 9139, the 5 and 10 mg/kg doses yield serum concentrations exceeding the MICs for the Coccidioides immitis test strain (0.8 and 1.5 μg/mL respectively) for periods in excess of 30 min after injection[1].


[1]. Hoeprich PD, et al. Activity of BAY n 7133 and BAY 1 9139 in vitro and in experimental murine coccidioidomycosis. Eur J Clin Microbiol. 1985 Aug;4(4):400-3.