GW7604 是一种抗雌激素药。GW7604 是 GW5638 的代谢物。GW5638 是一种高亲和力的雌激素受体 (ER) 拮抗剂。
CAS：195611-82-6
分子式：C25H22O3
分子量：370.44
纯度：98%
存储：Store at -20°C

Background:

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells

[1]. Bentrem D, et al. Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology. 2001 Feb;142(2):838-46.