LIN28 inhibitor LI71 是一种高效、细胞渗透性的 LIN28 抑制剂，能消除 LIN28 介导的寡核苷酸化，其 IC50 值为 7 uM。LIN28 inhibitor LI71 能直接绑定 CSD，抑制 LIN28 对 let-7 的作用活性。
CAS：1357248-83-9
分子式：C21H21NO3
分子量：335.4
纯度：98%
存储：Store at -20°C

Background:

LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells[1]. IC50: 7 uM (LIN28)[1]

[1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.