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BAM7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BAM7图片
CAS NO:331244-89-4
规格:98%
分子量:405.47
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
BAX activator,direct and selective
CAS:331244-89-4
分子式:C21H19N5O2S
分子量:405.47
纯度:98%
存储:Store at -20°C

Background:

BAM7 is a direct and selective activator of BAX with IC50 value of 3.3uM [1].


In the competitive fluorescence polarization assay (FPA), BAM7 competes with FITC–BIM SAHB for BAX binding site(BH3) in a dose dependent manner. BAM7 shows no antiapoptotic or BAKΔC competitive binding interactions even at 50 μM dosing, revealing a remarkable selectivity of BAM7 for BAX. The interaction between BAM7 and BAX at the very surface induces the characteristic structural changes that yield functional BAX oligomerization. In the in vitro assay, BAM7 induces BAX-dependent cell death but not the cells with BAK. BAM7 could be developed to a new generation of apoptotic modulators that directly activate BCL-2 family executioner proteins in cancer


and other diseases driven by pathologic apoptotic blockades [1].


参考文献:
[1] Evripidis Gavathiotis, Denis E Reyna, Joseph A Bellairs, Elizaveta S Leshchiner, and Loren D Walensky. Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 July ; 8(7): 639–645.