mGluR antagonist
CAS：150145-89-4
分子式：C10H11NO4
分子量：209.2
纯度：98%
存储：Store at -20°C

Background:

(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG [1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2].

In Vitro:(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures[1].

In Vivo:

Animal Model:    Male Lister-Hooded rats in the learning of the Morris water maze[2]    

Dosage:    20 μg    

Administration:    Intraventricular injection; 20 μg; 4 days    

Result:    Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.    

参考文献：

[1]. Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39(7):1130-7.

[2]. F Bordi, et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35(11):1557-65.