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TUG 891
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TUG 891图片
CAS NO:1374516-07-0
规格:98%
分子量:364.41
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
FFA4 (GPR120) agonist
CAS:1374516-07-0
分子式:C23H21FO3
分子量:364.41
纯度:98%
存储:Store at -20°C

Background:

TUG-891is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).


TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].


参考文献:
[1]. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25