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MCH-1 antagonist 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCH-1 antagonist 1图片
CAS NO:1039825-68-7
规格:98%
分子量:414.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MCH-1antagonist1是一种有效的黑色素浓缩激素1(MCH-1)拮抗剂,Ki值为2.6nM。MCH-1antagonist1还抑制CYP3A4,IC50为10μM。
CAS:1039825-68-7
分子式:C25H26N4O2
分子量:414.5
纯度:98%
存储:Store at -20°C

Background:

MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.


MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1].


MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1].


[1]. Henderson AJ, et al. Tetrahydrocarboline analogs as MCH-1 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7024-8.