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ITX3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ITX3图片
CAS NO:347323-96-0
规格:98%
分子量:371.45
包装与价格:
包装价格(元)
100mg电议
200mg电议
5mg电议
10mg电议
50mg电议

产品介绍
ITX3是无毒性的TrioN(N-terminal GEF domain of the multidomain Trio protein)抑制剂,IC50为76 uM,能体外抑制TrioN刺激的RhoG交换。
CAS:347323-96-0
分子式:C22H17N3OS
分子量:371.45
纯度:98%
存储:Store at -20°C

Background:

ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro.IC50 value: 76 uM [1]Target: TrioN inhibitorIn transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation while having no effect on GEF337-, Tiam1-, or Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its ability to inhibit neurite outgrowth in nerve growth factor (NGF)-stimulated PC12 cells or C2C12 differentiation into myotubes [1]. ITX3 repressed the Rac1 activity and dose dependently up-regulated the E-cadherin protein level in the Tara-KD cells [2].




[1]. Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16(6):657-66. [2]. Yano T, et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011 Apr 18;193(2):319-32.