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Alogliptin Benzoate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alogliptin Benzoate图片
CAS NO:850649-62-6
规格:98%
分子量:461.51
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
DPP-4 inhibitor,selective and potent,antidiabetic drug
CAS:850649-62-6
分子式:C25H27N5O4
分子量:461.51
纯度:98%
存储:Store at -20°C

Background:

Alogliptin is a novel, highly selective and potent inhibitor of serine protease dipeptidylpeptidase-4 (DPP-4) with IC50 value of less than 10 nM [1].


Alogliptin has been reported to significantly reduce plasma DPP-4 activity and increase active GLP-1 levels in a dose-dependent manner in ob/ob?mice. Besides, alogliptin after 4?weeks administration remarkably reduced non-fasting glycosylated hemoglobin, non-fasting plasma glucose and triglyceride levels, as well as siginificantly increased non-fasting plasma insulin and fasting pancreatic insulin content in ob/ob?mice. Moreover, alogliptin treated ob/ob?mice have shown the increase of early-phase insulin secretion and the decrease of plasma glucose AUC [2]


参考文献:
[1] Feng J,?Zhang Z,?Wallace MB,?Stafford JA,?Kaldor SW,?Kassel DB,?Navre M,?Shi L,?Skene RJ,?Asakawa T,?Takeuchi K,?Xu R,?Webb DR,?Gwaltney SL 2nd. Discovery?of?alogliptin: a?potent,?selective,?bioavailable, and?efficacious?inhibitor?of?dipeptidyl?peptidase?IV. J Med Chem.?2007 May 17;50(10):2297-300.
[2] Moritoh Y1,?Takeuchi K,?Asakawa T,?Kataoka O,?Odaka H. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice. Eur J Pharmacol.?2008 Jul 7;588(2-3):325-32.