BPH-652 is a squalene synthase (SQS) inhibitor or dehydrosqualene synthase (CrtM) inhibitor. BPH-652 targets the biosynthesis of Staphyloxanthin (STX). The essential nature of STX is to act as a virulence factor with antioxidant properties; indeed, unpigmented microbes are more susceptible to host killing. Therefore, the intervention of STX biosynthesis may offer a new avenue to treat S. aureus or even MRSA infections. References: Koyama N, Inokoshi J, Tomoda H. Anti-infectious agents against MRSA. Molecules. 2012 Dec 24;18(1):204-24. doi: 10.3390/molecules18010204. Review. PubMed PMID: 23262449.

纯度：≥98%

CAS：157124-84-0