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Tautomycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tautomycin图片
CAS NO:109946-35-2
包装:25ug
规格:98%
市场价:4815元
分子量:766.96

产品介绍
Tautomycin是可从Streptomycesverticillatus中分离得到的一种真菌类抗生素,是蛋白磷酸酶1和2A的有效特异性抑制剂,在没有Ca2+的情况下诱导平滑肌收缩,Kiapp值分别为0.16nM和0.4nM。
CAS:109946-35-2
分子式:C41H66O13
分子量:766.96
纯度:98%
存储:Store at -20°C

Background:

Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively[1][2].


MTC cell growth is inhibited in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].NE markers ASCL1 and CgA in human MTC cells are decreased in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].|| Cell Proliferation Assay[2]||Cell Line:|Human MTC cells|Concentration:|0-1000 nM|Incubation Time:|48 hours|Result:|Inhibited MTC cell growth in a dose-dependent manner.|| Western Blot Analysis[2]||Cell Line:|Human MTC cells|Concentration:|0-1000 nM|Incubation Time:|48 hours|Result:|Led to a dose-dependent decrease in the NE markers ASCL1 and CgA.



[1]. MacKintosh C, et al. Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS Lett. 1990 Dec 17;277(1-2):137-40. [2]. Adler JT, et al. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol Cancer Ther. 2009 Apr;8(4):914-20.