Kushenol A 是从苦参 (Sophora flavescent) 的根中分离出来的，一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种黄酮类抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) 和 β-淀粉酶(beta-amylase)具有抑制作用。Kushenol A 被证实是可用于化妆品的针对皮肤美白和衰老的潜在物质。
CAS：99217-63-7
分子式：C25H28O5
分子量：408.49
纯度：98%
存储：Store at -20°C

Background:

Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].

[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054. [2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.