REV7/REV3L-IN-1 是一种 REV7/REV3L 相互作用抑制剂，IC50 值为 78 μM，在核磁共振分析中，其直接与 REV7 结合，并抑制在启动子和报告子区域之间含有链间交联 (ICL) 的报告载体的再活化。
CAS：1979192-13-6
分子式：C19H21N3O3S
分子量：371.45
纯度：98%
存储：Store at -20°C

Background:

REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions[1]. IC50: 78 μM (REV7/REV3L interaction)[1]

[1]. Actis ML, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346.