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Foretinib(GSK1363089)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Foretinib(GSK1363089)图片
CAS NO:849217-64-7
规格:98%
分子量:632.65
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
VEGF and HGF receptor inhibitor
CAS:849217-64-7
分子式:C34H34F2N4O6
分子量:632.65
纯度:98%
存储:Store at -20°C

Background:

Foretinib (GSK1363089) is a novel, potent, small-molecule inhibitor of member of the vascular endothelial growth factor (VEGF)and hepatocyte growth factor (HGF) receptor tyrosine kinase families [1].


Foretinib inhibits Met, Ron, KDR, Flt-1, Flt-4, KIT, Flt-3, Platelet-derived growth factor receptor α, Platelet-derived growth factor receptor β and Tie-2 with IC50 values of 0.4, 3, 0.86, 6.8, 2.8, 6.7, 3.6, 3.6, 9.6 and 1.1 nmol/L, respectively. Foretinib has shown to inhibit cellular MET in murine B16F10 melanoma cells and PC-3 prostate cells with IC50 values of 21 and 23 nmol/L [1].


Foretinib revealed to inhibit the migration and invasion induced by HGF in murine B16F10 melanoma cells. Additionally, Foretinib suppressed the B16F10, A549 and HT29 tumor cells growth with IC50 values of 40, 29 and 165 nmol/L [1].


Reference:
[1] Qian F1, Engst S, Yamaguchi K, Yu P, Won KA, Mock L, Lou T, Tan J, Li C, Tam D, Lougheed J, Yakes FM, Bentzien F, Xu W, Zaks T, Wooster R,Greshock J, Joly AH.  Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 2009 Oct 15;69(20):8009-16. doi: 10.1158/0008-5472.CAN-08-4889.