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PROTO-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PROTO-1图片
CAS NO:312951-85-2
规格:98%
分子量:378.88
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
PROTO-1显著保护毛细胞,HC50(毛细胞存活50%时的浓度)为1μM-10μM(1μM≤HC50≤10μM)。
CAS:312951-85-2
分子式:C17H19ClN4O2S
分子量:378.88
纯度:98%
存储:Store at -20°C

Background:

PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).Target:PROTO-1 shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM. Pretreatment with 1 and 10 μM PROTO-1 results in significant protection of hair cells exposed to 200 μM neomycin compared to neomycin alone. PROTO-1 protection against neomycin is tested at 4 mM neomycin and showed significant striolar.[2]




[1]. Rubel, et al. COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH [2]. Owens KN, et al. Identification of genetic and chemicalm modulators of zebrafish mechanosensory hair cell death. PLoS Genet. 2008 Feb 29;4(2):e1000020.