MF-438 是一种有效且口服生物可利用的 stearoyl-CoA desaturase 1 (SCD1) 的抑制剂，对 rSCD1 的 EC50 值为 2.3 nM。
CAS：921605-87-0
分子式：C19H18F3N5OS
分子量：421.44
纯度：98%
存储：Store at -20°C

Background:

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1]. EC50: 2.3 nM (rSCD1)[1]

MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1].

[1]. LÉger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.