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RGX-104 free Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RGX-104 free Acid图片
CAS NO:610318-54-2
规格:98%
分子量:596.08
包装与价格:
包装价格(元)
200mg电议
500mg电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
RGX-104 free Acid 是具有口服生物活性的、有效的肝X核激素受体 (LXRβ) 激动剂,通过ApoE基因的转录激活调节先天免疫。
CAS:610318-54-2
分子式:C34H33ClF3NO3
分子量:596.08
纯度:98%
存储:Store at -20°C

Background:

RGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. LXR[1]



Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity[1]. Animal Model: NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells[1].


[1]. Tavazoie MF, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 Feb 8;172(4):825-840.e18.