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FH1(BRD-K4477)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FH1(BRD-K4477)图片
CAS NO:2719-05-3
规格:98%
分子量:282.34
包装与价格:
包装价格(元)
10mg电议
25mg电议

产品介绍
Enhance cultured hepatocyte function
CAS:2719-05-3
分子式:C17H18N2O2
分子量:282.34
纯度:98%
存储:Store at -20°C

Background:

FH1 is a small molecule that can enhance the functions of cultured hepatocytes [1].


FH1 belongs to the function-only hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. Besides that, FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps. Cultures treated with FH1 contain larger colonies of iHeps were with more pronounced hepatocyte morphologies. Moreover, treatment of FH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion [1].


参考文献:
[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.