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Prasugrel hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prasugrel hydrochloride图片
CAS NO:389574-19-0
规格:98%
分子量:409.9
包装与价格:
包装价格(元)
5mg电议
100mg电议

产品介绍
P2 Receptor inhibitor
CAS:389574-19-0
分子式:C20H21ClFNO3S
分子量:409.9
纯度:98%
存储:Store at -20°C

Background:

Prasugrel hydrochloride (PCR 4099 hydrochloride) is a platelet inhibitor with IC50 value of 1.8 μM.


Prasugrel (PCR 4099) is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI[2].Prasugrel (PCR 4099) reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel hydrochloride AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 Μm[2]].


参考文献:
[1]. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51. Epub 2007 Apr 19.
[2]. Baker WL, et al. Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes. Am J Cardiovasc Drugs. 2009;9(4):213-29.