您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Thienyldecyl Isothiocyanate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Thienyldecyl Isothiocyanate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thienyldecyl Isothiocyanate图片
CAS NO:288323-41-1
规格:98%
分子量:281.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
cytochrome P450 inhibitor
CAS:288323-41-1
分子式:C15H23NS2
分子量:281.5
纯度:98%
存储:Store at -20°C

Background:

Thienyldecyl isothiocyanate is a cytochrome P450 inhibitor [1].


The human cytochrome P450 (CYP), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. Until now, there are more than 270 different CYP gene families have been identified, with 18 recorded in mammals. It has been repoted that cytochrome P450 is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes result in inborn errors of metabolism and contribute to many clinically relevant diseases [2].


Thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. Thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. Thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes [1].


参考文献:
[1] Yu R, Mandlekar S, Harvey K J, et al.  Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity[J]. Cancer Research, 1998, 58(3): 402-408.
[2] Nebert D W, Russell D W.  Clinical importance of the cytochromes P450[J]. The Lancet, 2002, 360(9340): 1155-1162.