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Ticagrelor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ticagrelor图片
CAS NO:274693-27-5
规格:98%
分子量:522.57
包装与价格:
包装价格(元)
10mg电议
100mg电议
500mg电议

产品介绍
P2Y12 receptor antagonist
CAS:274693-27-5
分子式:C23H28F2N6O4S
分子量:522.57
纯度:98%
存储:Store at -20°C

Background:

Ticagrelor is a novel antagonist of the P2Y12 receptor [1].


Ticagrelor has been reported to inhibit the prothrombotic effects of ADP on the platelet by against the P2Y12 receptor. Ticagrelor has shown the complete inhibition of platelet aggregation ex vivo. In addition Ticagrelor has suggested a dose-dependent inhibition of platelet aggregation in human being. Apart from these, Ticagrelor has also demonstrated an orally, actively, reversibly binding antagonist. Unlike other inhibitors, Ticagrelor has also reported to inhibit P2Y12 receptor without metabolic transformation. Besides that, Ticagrelor is the first thienopyridine anti-platelet agent and mainly metabolized by CYP3A4 and CYP2C19 [1][2].


参考文献:
[1] Zhou D1, Andersson TB, Grimm SW. In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics. Drug Metab Dispos. 2011 Apr;39(4):703-10.
[2] Li Y1, Landqvist C, Grimm SW. Disposition and metabolism of ticagrelor, a novel P2Y12 receptor antagonist, in mice, rats, and marmosets. Drug Metab Dispos. 2011 Sep;39(9):1555-67. doi: 10.1124/dmd.111.039669. Epub 2011 Jun 13.