| CAS NO: | 364782-34-3 |
| 规格: | 98% |
| 分子量: | 393.87 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 500mg | 电议 |
Background:
Cinacalcet HCl (AMG 073), the second-generation calcimimetic, is a potent agonist of calcium-sensing receptor (CaR) with an EC50 value of 2.8 μm [1].
Cinacalcet HCl showed to be safe for the secondary hyperparathyroidism treatment. Besides, cinacalcet HCl has been proved to reduce parathyroid hormone (PTH) levels significantly while reducing the calcium x phosphorus product and serum phosphorus levels at the same time [1].
Administered orally with cinacalcet in Rice H-500 tumor?bearing mice has shown a significant reduction of blood ionized calcium, serum total calcium concentrations and serum PTHrP levels [2].
参考文献:
[1] Ure?a P1,?Fraz?o JM. Calcimimetic agents: review and perspectives. Kidney Int Suppl.?2003 Jun;(85):S91-6.
[2] Colloton M1,?Shatzen E,?Wiemann B,?Starnes C,?Scully S,?Henley C,?Martin D.Cinacalcet attenuates hypercalcemia observed in mice bearing either Rice H-500 Leydig cell or C26-DCT colon tumors. Eur J Pharmacol.?2013 Jul 15;712(1-3):8-15.
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