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Torsemide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Torsemide图片
CAS NO:56211-40-6
规格:98%
分子量:348.42
包装与价格:
包装价格(元)
10mg电议
25mg电议

产品介绍
pyridine-sulfonyl urea type loop diuretic
CAS:56211-40-6
分子式:C16H20N4O3S
分子量:348.42
纯度:98%
存储:Store at -20°C

Background:

Torsemide is a pyridine-sulfonyl urea type loop diuretic.Target: OthersTorasemide is a pyridine-sulfonylurea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. Torsemide significantly reduced total HF readmissions (relative risk [RR]: 0.41, 95% CI: 0.28-0.61, p< 0.0001) and HF readmissions (RR: 0.53, 95% CI: 0.33-0.84, p = 0.008) as well as CV readmissions (RR: 0.77, 95% CI: 0.60-0.98, p = 0.03) in patients with "at least 1 readmission." Torsemide caused a 14% reduction in all-cause mortality (RR: 0.86 [0.53-1.39], p = 0.54). Torsemide significantly reduces HF and CV-related hospital readmissions in systolic HF. Furthermore, torsemide is associated with a trend in reducing all-cause mortality [1]. Torsemide has several characteristics that make it suitable for treatment of advanced heart failure including longer half-life, increased potency of diuretic action, and anti-aldosterone effects. This case report details the administration of torsemide in 3 dogs with advanced heart failure and apparent furosemide resistance [2].


参考文献:
[1]. DiNicolantonio, J.J., Should torsemide be the loop diuretic of choice in systolic heart failure Future Cardiol, 2012. 8(5): p. 707-28.
[2]. Oyama, M.A., et al., Use of the loop diuretic torsemide in three dogs with advanced heart failure. J Vet Cardiol, 2011. 13(4): p. 287-92.