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O4I2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O4I2图片
CAS NO:165682-93-9
规格:98%
分子量:282.75
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Oct3/4 inducer
CAS:165682-93-9
分子式:C12H11ClN2O2S
分子量:282.75
纯度:98%
存储:Store at -20°C

Background:

Target: Oct3; Oct4


IC50: N/A


O4I2, a potent Oct3/4 inducer, is suitable for iPSC generation [1]. The octamer-binding transcription factor 4 (Oct3/4), a member of the POU family of transcription factors, is expressed specifically in pluripotent cells such as induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs). Oct3/4 plays a critical role in regulation of the cellular pluripotency core network. The loss-of-function mutation or suppression of Oct3/4 in embryonic stem cells (ESCs) leads to differentiation of ESCs into trophoblast and loss of pluripotency, whereas gain-of-function or forced overexpression Oct3/4, can reprogram somatic cells back into pluripotent stem cells (iPSCs) [1].


In vitro: O4I2 (5, 10, and 20 μM) dose-dependently activated Oct3/4 expression in HEK293 cells, embryonal NCCIT cells, and also in Oct-deficient HeLa cells [1]. In addition, O4I2 (10, and 20 μM) activated Oct3/4 on the transcriptional and translational level in human neonatal foreskin fibroblasts (HFFs), and promoted pluripotency-associated genes (Nanog and Lin28) expression [1].


In vivo: N/A


Reference:
1.  Cheng X, Yoshida H, Raoofi D, Saleh S, Alborzinia H, Wenke F, et al. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J Med Chem. 2015;58(15):5742-50.