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Tolnaftate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tolnaftate图片
CAS NO:2398-96-1
包装:50mg
规格:98%
市场价:592元
分子量:307.41

产品介绍
anti-fungal agent
CAS:2398-96-1
分子式:C19H17NOS
分子量:307.41
纯度:98%
存储:Store at -20°C

Background:

Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .


Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans[1]. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid[2].


参考文献:
[1]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60.
[2]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81.