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all-trans Retinal
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
all-trans Retinal图片
CAS NO:116-31-4
规格:98%
分子量:284.4
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议

产品介绍
converted to retinoic acid in vivo
CAS:116-31-4
分子式:C20H28O
分子量:284.4
纯度:98%
存储:Store at -20°C

Background:

All-trans Retinal, also known as Vitamin A aldehyde or Retinaldehyde, is one of the many forms of vitamin A and also the oxidation product of all-trans retinol [1]. All-trans Retinal are associated with one of the two isoforms of cellular retinol-binding proteins (CRBP-I and CRBP-II) with Kd values of 50 and 90 nM, respectively [1].


CRBP-I and CRBP-II were the first intracellular retinoid-binding proteins. Both proteins display a similar binding affinity towards retinal. They play important roles in retinoid biology and regulation of the metabolism of retinol and retinal. CRBP-I is used to regulate vitamin A storage and synthesis of retinoic acid. And CRBP-II has a role in the initial processing of retinol from food [1].


All-trans Retinal is one form of vitamin A. All-trans Retinal, the initial substrate of retinoid cycle, is a chemically reactive aldehyde that can form toxic conjugates with proteins and lipids, leading to degeneration of the retina [2].


参考文献:
[1].  Noy N. Retinoid-binding proteins: mediators of retinoid action. Biochem J. 2000 Jun 15;348 Pt 3:481-95.
[2].  Kiser PD, Golczak M, Maeda A, et al. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan;1821(1):137-51.