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BNP-45 rat(Brain natriuretic peptide-45 rat)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:123337-89-3
规格:98%
分子量:5040.67
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
BNP-45(rat)是由45个氨基酸组成的脑钠肽,从大鼠心脏中获得,为具有促尿钠排泄剂降血压活性的循环激素。
CAS:123337-89-3
分子式:C213H349N71O65S3
分子量:5040.67
纯度:98%
存储:Store at -20°C

Background:

BNP-45 (rat), a 45-amino acid brain natriurctic peptide isolated from rat heart, is a circulating hormone, with natriuretic andhypotensive activities.


BNP-45 (rat), a 45-amino acid brain natriurctic peptide isolated from rat heart, is a circulating hormone, with natriuretic andhypotensive activities[1].


BNP-45 (rat) (0.1, O.2, 0.5, 1.0 and 2.0 nmol/kg, i.v.) shows potent natriuretic and hypotensive activities in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). BNP-45 (rat) with high concentration decreases blood pressure in SHR. But WKY is more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. In addition, high dose of BNP-45 (rat) cuases prolonged lowering of blood pressure and urinary cGMP excretion in WKY[1].


[1]. Kita T, et al. Effects of brain natriuretic peptide-45, a circulating form of rat brain natriuretic peptide, in spontaneously hypertensive rats. Eur J Pharmacol. 1991 Sep 4;202(1):73-9.