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LOM612
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LOM612图片
CAS NO:2173232-79-4
规格:98%
分子量:258.3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
LOM612是一种有效的FOXO核移位激活剂,在细胞中EC50值为1.5μM。
CAS:2173232-79-4
分子式:C13H10N2O2S
分子量:258.3
纯度:98%
存储:Store at -20°C

Background:

LOM612 is a potent activator of FOXO nuclear translocation, with an EC50 value of 1.5 μM in cells.


LOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 μM)[1].



[1]. Cautain B, et al. Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS One. 2016 Dec 9;11(12):e0167491.