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Nitracrine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nitracrine图片
CAS NO:4533-39-5
规格:98%
分子量:324.38
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Nitracrine是一种已在临床上使用数年的抗肿瘤药物。
CAS:4533-39-5
分子式:C18H20N4O2
分子量:324.38
纯度:98%
存储:Store at -20°C

Background:

Nitracrine is an antitumor drug that has been used clinically for several years.


It is demonstrated during the reduction of ledakrin that a key metabolite, a compound with anadditional five-membered ring attaching to positions 1 and 9 of the acridine core and with the retained 9-aminoalkyl side chain, is formed in all the systems that are studied. It is determined that the reactive nitrogen atoms of this additional ring undergo further transformations resulting in the formation of a six-membered ring produced by the addition of a carbon atom to the dihydropyrazoloacridine ring. Furthermore, it is observed that positions 2 and 4 of ledakrin’s acridine ring are susceptible to nucleophilic substitution as revealing by the studies with dithiothreitol. Additionally, although most products from the reduction of ledakrin are extremely unstable, 1-aminoacridinone, producing enzymatically and with dithiothreitol, exhibiting persistent stability under the studied conditions[1].



[1]. Gorlewska K, et al. Products of metabolic activation of the antitumor drug ledakrin (nitracrine) in vitro.