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S-(2-aminoethyl)Isothiourea(dihydrobromide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-(2-aminoethyl)Isothiourea(dihydrobromide)图片
CAS NO:56-10-0
包装:25g
规格:98%
市场价:365元
分子量:281

产品介绍
non-selective inhibitor of all NOS isoforms
CAS:56-10-0
分子式:C3H9N3S · 2HBr
分子量:281
纯度:98%
存储:Store at -20°C

Background:

S-(2-aminoethyl) Isothiourea (dihydrobromide) is a potent and non-selective inhibitor of NOS with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].


In the brain, nitric oxide (NO), which is synthesized from L-arginine (Arg) by NO synthase (NOS), acts as both an intra- and an intercellular second messenger. Nitric oxide synthase (iNOS, eNOS, and nNOS) catalyzed the production of NO in the two-step oxidation of L-arginine. The three isozymes produce NO in separate tissues for different purposes in both normal and diseased states [1].


S-(2-aminoethyl) Isothiourea is a potent and non-selective NOS inhibitor with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].


Reference:
[1].  Garvey EP, Oplinger JA, Tanoury GJ, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76.