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MAC13243
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MAC13243图片
CAS NO:1071638-38-4
规格:98%
分子量:442.4
包装与价格:
包装价格(元)
200mg电议
500mg电议
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
MAC13243是抗菌剂。
CAS:1071638-38-4
分子式:C20H25Cl2N3O2S
分子量:442.4
纯度:98%
存储:Store at -20°C

Background:

MAC13243, an antibacterial agent, is a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA.IC50 Value: Target: AntibacterialMAC13243, a molecule that belongs to a new chemical class and that has a unique mechanism and promising activity against multidrug-resistant Pseudomonas aeruginosa. MAC13243 inhibits the function of the LolA protein and represents a new chemical probe of lipoprotein targeting in bacteria with promise as an antibacterial lead with Gram-negative selectivity.




[1]. Barker CA, et al. Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2426-31. [2]. Pathania R, et al. Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nat Chem Biol. 2009 Nov;5(11):849-56.