您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Neurokinin A(4-10)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Neurokinin A(4-10)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neurokinin A(4-10)图片
CAS NO:97559-35-8
规格:98%
分子量:766.91
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Neurokinin A (4-10) 是速激肽 NK2 受体激动剂。
CAS:97559-35-8
分子式:C34H54N8O10S
分子量:766.91
纯度:98%
存储:Store at -20°C

Background:

Neurokinin A (4-10) is a tachykinin NK2 receptor agonist. NK2 receptor[1]


Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].



[1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.