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N-Nornuciferine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Nornuciferine图片
CAS NO:4846-19-9
规格:98%
分子量:281.35
包装与价格:
包装价格(元)
100mg电议
50mg电议
5mg电议
10mg电议

产品介绍
N-Nornuciferine是荷叶中的阿朴啡生物碱,可显着抑制 CYP2D6活性, IC50 和 Ki 值分为3.76 和2.34 μM。
CAS:4846-19-9
分子式:C18H19NO2
分子量:281.35
纯度:98%
存储:Store at -20°C

Background:

N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively. IC50: 3.76 μM (CYP2D6)[1]Ki: 2.34 μM (CYP2D6)[1]


The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent Ki values of 2.34 μM[1].



[1]. Ye LH, et al. Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol. 2014 Apr 11;153(1):190-6.