您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Morroniside
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Morroniside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Morroniside图片
CAS NO:25406-64-8
包装:20mg
规格:98%
市场价:2301元
分子量:406.15

产品介绍
Extracted from Cornus officinalis Sieb. et Zucc.;Store the product in sealed,cool and dry condition
CAS:25406-64-8
分子式:C17H26O11
分子量:406.15
纯度:98%
存储:Store at -20°C

Background:

Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.


Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/R?associated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase?3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl?2 is significantly downregulated. The expression of active caspase?3 and Bax is significantly downregulated by Morroniside treatment in a dose?dependent manner, while the expression of Bcl?2 is significantly upregulated[1]. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice[2].


参考文献:
[1]. Zeng G, et al. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16(3):2229-2234.
[2]. Park CH, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34(10):1559-65.