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Misoprostol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Misoprostol图片
CAS NO:59122-46-2
包装:5mg
规格:98%
市场价:453元
分子量:382.53

产品介绍
synthetic prostaglandin E1 (PGE1) analog
CAS:59122-46-2
分子式:C22H38O5
分子量:382.53
纯度:98%
存储:Store at -20°C

Background:

Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion.Target: Prostaglandin ReceptorMisoprostol is a synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. Administration of misoprostol to EP3+/+ and EP3-/- mice showed similar levels of infarct rescue, indicating that misoprostol protection was not mediated through the EP3 receptor. Taken together, these findings suggest a novel function for misoprostol as a protective agent in cerebral ischemia acting via the PGE(2) EP2 and/or EP4 receptors [1, 2].


参考文献:
[1]. Li, J., et al., Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia. Neurosci Lett, 2008. 438(2): p. 210-5.
[2]. http://www.drugbank.ca/drugs/DB00929