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ATB-346
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ATB-346图片
CAS NO:1226895-20-0
规格:98%
分子量:365.45
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Non-steroidal anti-inflammatory drug
CAS:1226895-20-0
分子式:C21H19NO3S
分子量:365.45
纯度:98%
存储:Store at -20°C

Background:

ATB-346 is a hydrogen sulphide-releasing anti-inflammatory drug [1].


ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) and shows a markedly reduced toxicity than its parent compound naproxen. In the airpouch model, ATB-346 significantly inhibited the PGE2 level and completely suppressed the whole blood TXB2 synthesis without causing gastric damage. In rats with adjuvant-Induced arthritis, administration of ATB-346 reduced the paw volume on days 14 and 21 notably. ATB-346 did not exert any damage or bleeding in the stomach or small intestine while naproxen caused bleeding in the small intestine. Besides that, administration of naproxen twice daily for 5 days in rats resulted in extensive damage in the small intestine. In contrast, same dose of ATB-346 caused quite little damage over the treatment of the 5 days [1].


参考文献:
[1] Wallace J L, Caliendo G, Santagada V, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). British journal of pharmacology, 2010, 159(6): 1236-1246.