MTP-IN-1是微粒体甘油三酯转移蛋白(microsomaltriglyceridetransferprotein(MTP))抑制剂，IC50值为0.77±0.29nM。
CAS：863491-70-7
分子式：C42H37FN4O4
分子量：680.77
纯度：98%
存储：Store at -20°C

Background:

PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.

PF-02575799 is compound 13 from the reference[1].

PF-02575799 produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg). PF-02575799 significant increase alanine transaminase at 100 mg/kg[1].

[1]. Robinson RP, et al. Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4150-4.