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CAY10700
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAY10700图片
CAS NO:1381846-21-4
规格:98%
分子量:334.8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Prostaglandin E2 is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases.
CAS:1381846-21-4
分子式:C16H19ClN4O2
分子量:334.8
纯度:98%
存储:Store at -20°C

Background:

Prostaglandin E2 is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both COX-2 and microsomal PGE synthase-1 (mPGES-1). CAY10700 is an orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 uM in an in vitro human whole blood assay). It is inactive against COX-1 and COX-2 (9% inhibition at 100 uM and 16% at 30 uM, respectively).


参考文献:
[1].Schiffler, M.A., Antonysamy, S., Bhattachar, S.N., et al. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors Journal of Medicinal Chemistry 59(1), 194-205 (2016).