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VK3-OCH3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VK3-OCH3图片
CAS NO:255906-59-3
规格:98%
分子量:262.3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
VK3-OCH3 is an analog of vitamin K3 that that has antiproliferative activities in vitro.
CAS:255906-59-3
分子式:C14H14O3S
分子量:262.3
纯度:98%
存储:Store at -20°C

Background:

VK3-OCH3 is an analog of vitamin K3 that that has antiproliferative activities in vitro. It preferentially decreases proliferation of IMR-32, LA-N-1, NB-39, and SK-N-SH neuroblastoma cells (IC50s = 2.43, 1.55, 10.69, and 3.45 µM, respectively) compared with non-cancerous HUVEC and HDF cells (IC50s = 26.24 and 87.11 µM, respectively). It increases heme oxygenase-1 (HO-1) and caveolin-1 levels, induces apoptosis, and halts the cell cycle at the G2/M phase in IMR-32 cells. VK3-OCH3 also inhibits protein-tyrosine phosphorylase (PTPase) activity (IC50 = 57.2 µM in a cell-free assay), induces protein-tyrosine phosphorylation in Hep3B hepatoma cells when used at a concentration of 50 µM, and inhibits the growth of Hep3B cells (IC50 = 8.6 µM).