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Scyliorhinin II
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:112748-19-3
规格:98%
分子量:1851.09
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
ScyliorhininII是一种选择性的神经激肽-3(neurokinin-3tachykinin)受体激动剂,对大鼠脑皮层的neurokinin-3受体的Ki值为2.5nM。
CAS:112748-19-3
分子式:C77H119N21O26S3
分子量:1851.09
纯度:98%
存储:Store at -20°C

Background:

Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.


Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200[1].


Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2].


[1]. Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. [2]. Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91.