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Quadrol(N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quadrol(N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine)图片
CAS NO:102-60-3
包装:10g
规格:98%
市场价:445元
分子量:292.41

产品介绍
Quadrol是一种免疫刺激剂,已被认为是加速伤口愈合的潜在有用药物。
CAS:102-60-3
分子式:C14H32N2O4
分子量:292.41
纯度:98%
存储:Store at -20°C

Background:

Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing.


Results show that viability of macrophages incubated with Quadrol at concentrations of 0.5 mM, 1 mM and 4mM are identical to that for controls. Viability, however, is reduced to 50% of control at concentrations of 16 mM to 32 mM. After four hours, at concentrations of 1 mM and 4 mM, Quadrol produces enhanced spreading of 88% and 80%, respectively, as compared to the control of 28%. Quadrol, at a concentration of 16 mM, shows reduced percentage of spreading of macrophages after four hours. Exposure of macrophages to 1.0 mM or 4.0 mM Quadrol concentrations enhances phagocytic activity, 41% and 57%, respectively, over that of the cells exposed to media alone (34%)[1].


On day eight after the implantation, the amount of collagen in the implants of normal mice injected with Quadrol exceeds controls by more than 200% (p<0.025). By day 11, the collagen content increases to over 300% higher than controls (p<0.01) and by the end of two weeks after wounding, the time interval typically required for normal and complete wound healing, the collagen accumulated in the implants of the Quadrol-treated mice is about 50% above control (p<0.1). The accumulation of collagen in the implants of Quadrol treated STZ-diabetic mice about 100% above the untreated diabetic control on days 8 to 11. By day 14, the collagen deposition has increased to 200% above the controls (p<0.0 5)[2].


[1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N’,N’-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12. [2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22.