SAR125844是一种有效的、高度选择性的、可逆的、ATP竞争性的MET受体酪氨酸激酶(RTK)的静脉给药抑制剂，其IC50值为4.2nM。能抑制细胞中MET的自磷酸化。
CAS：1116743-46-4
分子式：C25H23FN8O2S2
分子量：550.63
纯度：98%
存储：Store at -20°C

Background:

SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor for intravenous administration, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays[1].

[1]. Egile C, et al. The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer. Mol Cancer Ther. 2015 Feb;14(2):384-94.