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Teicoplanin A2-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Teicoplanin A2-3图片
CAS NO:91032-36-9
规格:98%
分子量:1879.7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
glycopeptide antibiotic
CAS:91032-36-9
分子式:C88H97Cl2N9O33
分子量:1879.7
纯度:98%
存储:Store at -20°C

Background:

Teicoplanin A2-3 is a major component of the teicoplanin complex [1-3].


Teicoplanins, lipoglycopeptide antibiotics, are glycopeptide antibiotics produced by A. teichomyceticus that are broadly effective against Gram-positive bacteria in vitro. Teicoplanins consist of five major components (A2-1, A2-2, A2-3, A2-4 and A2-5), one hydrolysis component (A3-1), and four minor components (RS-1, RS-2, RS-3, RS-4) [1]. Teicoplanins have been recently used for the treatment of multitudinous aerobic and anaerobic Gram-positive infections. Teicoplanins have been rapidly and extensively absorbed from the peritoneal cavity and muscle, but very poorly absorbed from the gastrointestinal tract [2]. Teicoplanin is highly bound in plasma to albumin and in tissues. Both renal and nonrenal mechanisms have been implicated in the elimination of the drug. For at least after one day administration, the concentrations of teicoplanin in serum and urine exceeded the MIC ranging from 0.02-2 μg/ml on many pathogenic organisms [3].


参考文献:
[1] Bernareggi A, Borghi A, Borgonovi M, et al.  Teicoplanin metabolism in humans[J]. Antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749.
[2] Rowland M.  Clinical pharmacokinetics of teicoplanin[J]. Clinical pharmacokinetics, 1990, 18(3): 184-209.
[3] Traina G L, Bonati M.  Pharmacokinetics of teicoplanin in man after intravenous administration[J]. Journal of Pharmacokinetics and Pharmacodynamics, 1984, 12(2): 119-128.