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EOS(d18:1/30:0/18:2)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EOS(d18:1/30:0/18:2)图片
CAS NO:97040-38-5
包装:1mg
规格:98%
市场价:8896元
分子量:1012.7

产品介绍
EOS is a ceramide found in the outer layer of the epidermis in mammals.
CAS:97040-38-5
分子式:C66H125NO5
分子量:1012.7
纯度:98%
存储:Store at -20°C

Background:

EOS is a ceramide found in the outer layer of the epidermis in mammals. It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid . The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte. EOS (d18:1/30:0/18:2) is a sphingolipid that has been found in intact and desquamated human stratum corneum as well as porcine epidermis.