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IQ-R
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IQ-R图片
CAS NO:1345445-57-9
规格:98%
分子量:576.6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
IQ-R是一种新颖的缺氧敏感荧光探针,包括一个吲哚醌和对甲氨基酚荧光基团。
CAS:1345445-57-9
分子式:C34H28N2O7
分子量:576.6
纯度:98%
存储:Store at -20°C

Background:

IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore.Target:IQ-R has good solubility in water and longer wavelength for absorption and emission, which are favorable for cellular bioimaging. While the fluorescence of rhodol in the IQ-R conjugate is quenched by the function of intramolecular indolequinone unit, it is restored under hypoxic conditions through the enzymatic one-electron reduction of IQ-R by NADPH: cytochrome P450 reductase to release the nonconjugated free rhodol. When administered to A549 cells, IQ-R is activated and reduced by endogenous reductase preferentially under hypoxic conditions, thereby visualizing hypoxic cancer cells by robust fluorescence.




[1]. Hirokazu Komatsu,et al. Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties. Med. Chem. Commun., 2010,1, 50-53