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CS476(NSC302998)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CS476(NSC302998)图片
CAS NO:41177-35-9
规格:98%
分子量:471.57
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
CS476是一种有效的降血糖试剂。
CAS:41177-35-9
分子式:C24H29N3O5S
分子量:471.57
纯度:98%
存储:Store at -20°C

Background:

CS476 is a potent hypoglycaemic agent.



In normal fasting dogs, rabbits, rats and mice the maximal hypoglycaemia produced by intravenous administration of CS476 is comparable on a weight basis to that produced by Glibenclamide. Randomized Latin square experiments in dogs show that 0.03 mg/kg orally of CS476 and of Glibenclamide cause the same maximal decrease of blood glucose and that CS476 has the shorter duration of action. CS476 has no hypoglycaemic effect in totally pancreatectomized dogs nor in streptozotocin diabetic dogs and rats. The insulin releasing activity is studied in dogs after intravenous and oral administration of equipotent doses of CS476, Tolbutamide and Glibenclamide[1].


[1]. Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-m-carboxamido)-ethyl)-benzenesulphonyl]-N’-cyclohexylurea (NOVO CS 476). I. Pharmacological studies on the hypoglycaemic effect. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):216-26.