您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > C29
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
C29
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C29图片
CAS NO:363600-92-4
规格:98%
分子量:285.29
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
C29是Toll样受体2(Toll-likereceptor2(TLR2))抑制剂。
CAS:363600-92-4
分子式:C16H15NO4
分子量:285.29
纯度:98%
存储:Store at -20°C

Background:

C29 is a Toll-like receptor 2 (TLR2) inhibitor.


C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB-luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB-sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation[1].



[1]. Vogel S, et al. Small molecule inhibitors of tlr2 signaling. WO2016164414A1