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(±)-Medicarpin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-Medicarpin图片
CAS NO:33983-39-0
规格:98%
分子量:270.28
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
(±)-Medicarpin 是一种异黄酮,可以从具有各种生物学效应的几种药用植物中分离出来,包括作为植物抗毒素的槐花 (Sophora japonica),具有抗真菌特性的 Zollernia paraensis 和 Platymiscium yucatamun,具有细胞毒性作用的 Machaerium aristulatum,Platymiscium floribundum 和巴西红蜂胶,以及作为杀幼虫剂的 Dalbergia oliveri。(±)-Medicarpin 有效抑制破骨细胞生成,防止雌激素缺乏性骨质流失,但不影响子宫雌激素。 它还通过雌激素受体 (ER) β 介导的成骨作用的成骨细胞分化促进骨愈合并增加骨量。
CAS:33983-39-0
分子式:C16H14O4
分子量:270.28
纯度:98%
存储:Store at -20°C

Background:

(±)-Medicarpin is a pterocarpan, a type of isoflavonoid. (±)-Medicarpin has been isolated from several medicinal plant species with various biological effects, including Sophora japonica as a phytoalexin, Zollernia paraensis and Platymiscium yucatamun with antifungal properties, Machaerium aristulatum, Platymiscium floribundum, and Brazilian red propolis with cytotoxic effects, and Dalbergia oliveri as a larvicidal compound. (±)-Medicarpin potently inhibits osteoclastogenesis and prevents estrogen-deficient bone loss but does not display uterine estrogenicity. It also promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action[1]. ERβ




[1]. Yang X, et al. Total Synthesis of (+)-Medicarpin. J Nat Prod. 2017 Dec 22;80(12):3284-3288.