您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Bioymifi
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Bioymifi
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bioymifi图片
CAS NO:1420071-30-2
规格:98%
分子量:494.32
包装与价格:
包装价格(元)
200mg电议
500mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Bioymifi是第一个新型TRAIL受体DR5小分子激动剂。
CAS:1420071-30-2
分子式:C22H12BrN3O4S
分子量:494.32
纯度:98%
存储:Store at -20°C

Background:

Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.IC50 value:Target: In comparison with A2C2, bioymifi was able to promote cell death without the need for the Smac mimetic in T98G cells. Notably, at a 10-μM concentration, bioymifi induced processing of caspase-3 into smaller fragments. Z-VAD inhibited these caspase-mediated cleavages. caspase-3 was rapidly activated as early as 2 h after bioymifi treatment of T98G cells. The caspase-3 activity was markedly increased after 8 h of treatment. Bioymifi induces caspase-8-dependent apoptosis.




[1]. Wang G, et al. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol. 2013 Feb;9(2):84-9.